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Publication Detail
The FLIGHT Drosophila RNAi database 2010 update
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Sims D, Bursteinas B, Jain E, Gao QO, Baum B, Zvelebil M
  • Publisher:
    LANDES BIOSCIENCE
  • Publication date:
    10/2010
  • Pagination:
    344, 348
  • Journal:
    FLY
  • Volume:
    4
  • Issue:
    4
  • Print ISSN:
    1933-6934
  • Language:
    EN
  • Keywords:
    RNAi, database, integration, bioinformatics, phenotype, CAENORHABDITIS-ELEGANS, GENE ONTOLOGY, GENOME, SCREENS, INTERFERENCE, TOOL
  • Addresses:
    Sims, D
    UCL
    Inst Canc Res
    Breakthrough Breast Canc Res Ctr
    London
    England
Abstract
FLIGHT (http://flight.icr.ac.uk/) is an online resource compiling data from high-throughput Drosophila in vivo and in vitro RNAi screens. FLIGHT includes details of RNAi reagents and their predicted off-target effects, alongside RNAi screen hits, scores and phenotypes, including images from high-content screens. The latest release of FLIGHT is designed to enable users to upload, analyze, integrate and share their own RNAi screens. Users can perform multiple normalizations, view quality control plots, detect and assign screen hits and compare hits from multiple screens using a variety of methods including hierarchical clustering. FLIGHT integrates RNAi screen data with microarray gene expression as well as genomic annotations and genetic/physical interaction datasets to provide a single interface for RNAi screen analysis and data-mining in Drosophila.
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