UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The Hippo pathway regulates apical-domain size independently of its growth-control function.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Genevet A, Polesello C, Blight K, Robertson F, Collinson LM, Pichaud F, Tapon N
  • Publication date:
    15/07/2009
  • Pagination:
    2360, 2370
  • Journal:
    J Cell Sci
  • Volume:
    122
  • Issue:
    Pt 14
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0021-9533
  • PII:
    jcs.041806
  • Language:
    eng
  • Keywords:
    Adherens Junctions, Animals, Apoptosis, Cadherins, Cell Membrane, Cell Polarity, Cell Proliferation, Drosophila, Drosophila Proteins, Epithelial Cells, Genotype, Hypertrophy, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Mutation, Nuclear Proteins, Phenotype, Protein Kinase C, Protein-Serine-Threonine Kinases, Receptors, Notch, Signal Transduction, Trans-Activators, Wings, Animal
Abstract
The Hippo pathway, identified in Drosophila and conserved in vertebrates, regulates tissue growth by promoting cell cycle exit and apoptosis. In addition to their well-characterised overproliferation phenotype, adult Drosophila epithelial cells mutant for the kinases Hippo and Warts have hypertrophic apical domains. Here we examine the molecular basis of this apical hypertrophy and its impact on cell proliferation. In the wing imaginal disc epithelium, we observe increased staining for members of the apical polarity complexes aPKC and Crumbs as well as adherens junction components when Hippo activity is compromised, while basolateral markers are not affected. This increase in apical proteins is correlated with a hypertrophy of the apical domain and adherens junctions. The cell surface localisation of the Notch receptor is also increased in mutant clones, opening the possibility that aberrant receptor signalling may participate in overgrowth of hpo-deficient tissue. Interestingly, however, although the polarity determinant Crumbs is required for the accumulation of apical proteins, this does not appear to significantly contribute to the overproliferation defect elicited by loss of Hippo signalling. Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Lab for Molecular Cell Bio MRC-UCL
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by