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Publication Detail
Cross-sectional analysis using voxel or surface based cortical thickness methods: a comparison study
  • Publication Type:
  • Authors:
    Clarkson MJ, Cardoso M, Modat M, Ridgway GR, Leung KK, Rohrer J, Fox NC, Ourselin S
  • Publisher:
  • Publication date:
  • Place of publication:
    Piscataway, US
  • Pagination:
    381, 384
  • Published proceedings:
    2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro: Proceedings: March 30 – April 2, 2011 Chicago, Illinois, USA
  • ISBN-13:
  • Status:
  • Name of conference:
    8th International Symposium on Biomedical Imaging (ISBI’11)
  • Conference place:
    Chicago, US
  • Conference start date:
  • Conference finish date:
  • Print ISSN:
  • Keywords:
    Cortical thickness estimation, Laplacian, Registration, FreeSurfer
Cortical thickness estimation performed in-vivo via magnetic resonance imaging is an important technique for the diagnosis and understanding of the progression of neurodegenerative diseases. Currently, two different computational paradigms exist, with methods generally classified as either surface or voxel-based. This paper provides a much needed comparison of the surface-based method FreeSurfer and two voxel-based methods using clinical data. We demonstrate that voxel-based methods can detect similar patterns of group-wise differences as well as FreeSurfer, where the lack of deformable model constraints may provide more sensitivity but with a resulting trade-off in reproducibility.
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Dept of Med Phys & Biomedical Eng
Neurodegenerative Diseases
Dept of Med Phys & Biomedical Eng
Neurodegenerative Diseases
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