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Publication Detail
The Role of Genetics in Age-Related Hearing Loss
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    DAWSON S
  • Publisher:
    Pinpoint Scotland Ltd
  • Publication date:
    09/2010
  • Place of publication:
    Uk
  • Pagination:
    100, 102
  • Journal:
    ENT & Audiology News
  • Volume:
    19
  • Issue:
    4
  • Status:
    Published
  • Country:
    UK
  • Print ISSN:
    1368-8944
  • Language:
    English
  • Keywords:
    genetics, hearing, ageing
Abstract
When evaluating the role of genetics in age related hearing loss (ARHL) it is startling to realise that long standing questions about the aetiology of ARHL still remain unanswered. Where is the site of most significant damage which initiates the pathology: stria, neuronal, sensory epithelium or a mixture of these pathologies? Are there distinct pathologies in males and females or is the increased ARHL in males due to environmental exposure? What contribution do environmental agents particularly noise make to ARHL; are differences in sensitivity to these agents a risk factor for ARHL? It is hoped that an analysis of the inherited component of ARHL will reveal the genetic risk factors and provide the answer to these questions in the same way that it has revealed the inner ear biology that underlies different forms of deafness. In this respect, genetic analysis is very much a tool to identify the hidden biological mechanism rather than to provide information on an individual’s risk of ARHL.
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