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Publication Detail
Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Reddy BD, Wang Y, Niu L, Higuchi EC, Marguerat SB, Bähler J, Smith GR, Jia S
  • Publication date:
  • Pagination:
    214, 219
  • Journal:
    Genes Dev
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • PII:
  • Language:
  • Keywords:
    Centromere, Heterochromatin, Histone Acetyltransferases, RNA Interference, RNA Polymerase II, Schizosaccharomyces, Schizosaccharomyces pombe Proteins
In Schizosaccharomyces pombe, the RNAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregation, and repression of pericentric meiotic recombination. Here we demonstrate that, when the activity of the histone H3 Lys 14 (H3K14) acetyltransferase Mst2 is eliminated, the RNAi machinery is no longer required for pericentric heterochromatin functions. We further reveal that reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heterochromatin in the absence of RNAi.
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