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Publication Detail
Forming of Protein Bubbles and Porous Films Using Co-Axial Electrohydrodynamic Flow Processing
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ekemen Z, Ahmad Z, Edirisinghe M, Stride E
  • Publisher:
    WILEY-V C H VERLAG GMBH
  • Publication date:
    14/01/2011
  • Pagination:
    8, 13
  • Journal:
    MACROMOL MATER ENG
  • Volume:
    296
  • Issue:
    1
  • Print ISSN:
    1438-7492
  • Language:
    EN
  • Keywords:
    electrohydrodynamic, films, microbubbling, porous, protein, BOVINE SERUM-ALBUMIN, CONTRAST AGENT, ATOMIZATION, ULTRASOUND
  • Addresses:
    Ahmad, Z
    UCL
    Dept Mech Engn
    London
    WC1E 7JE
    England
Abstract
Air and 5 wt.-% BSA solution are used as a model system to generate protein-coated microbubbles, which are significantly smaller in diameter than the processing needle apertures. The effects of processing parameters (applied voltage and flow rate) on the bubble size distribution and stability are studied. The optimal processing conditions are also explored in terms of heating of the solutions and prepared structures. Both individual microbubbles and porous films were successfully prepared using this method which has significant potential for the preparation of microbubbles for drug delivery systems, porous coatings, thin films, scaffolds and ultrasound contrast agents. The versatile nature of the method implies that many macromolecules and other active agents can be used.
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Dept of Mechanical Engineering
Dept of Mechanical Engineering
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