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Publication Detail
The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Thomas BA, Erlandsson K, Modat M, Thurfjell L, Vandenberghe R, Ourselin S, Hutton BF
  • Publication date:
    06/2011
  • Pagination:
    1104, 1119
  • Journal:
    Eur J Nucl Med Mol Imaging
  • Volume:
    38
  • Issue:
    6
  • Status:
    Published
  • Country:
    Germany
  • Print ISSN:
    1619-7089
  • Language:
    eng
  • Keywords:
    Adult, Aged, Algorithms, Alzheimer Disease, Brain, Clinical Trials as Topic, Humans, Phantoms, Imaging, Positron-Emission Tomography
Abstract
Alzheimer's disease (AD) is the most common form of dementia. Clinically, it is characterized by progressive cognitive and functional impairment with structural hallmarks of cortical atrophy and ventricular expansion. Amyloid plaque aggregation is also known to occur in AD subjects. In-vivo imaging of amyloid plaques is now possible with positron emission tomography (PET) radioligands. PET imaging suffers from a degrading phenomenon known as the partial volume effect (PVE). The quantitative accuracy of PET images is reduced by PVEs primarily due to the limited spatial resolution of the scanner. The degree of PVE is influenced by structure size, with smaller structures tending to suffer from more severe PVEs such as atrophied grey matter regions. The aims of this paper were to investigate the effect of partial volume correction (PVC) on the quantification of amyloid PET and to highlight the importance of selecting an appropriate PVC technique.
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