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Publication Detail
Cost-effectiveness of balloon kyphoplasty in patients with symptomatic vertebral compression fractures in a UK setting.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Clinical Trial, Phase III
  • Authors:
    Ström O, Leonard C, Marsh D, Cooper C
  • Publication date:
    09/2010
  • Pagination:
    1599, 1608
  • Journal:
    Osteoporos Int
  • Volume:
    21
  • Issue:
    9
  • Status:
    Published
  • Country:
    England
  • Language:
    eng
  • Keywords:
    Aged, Catheterization, Cost-Benefit Analysis, Female, Fractures, Compression, Great Britain, Health Care Costs, Humans, Kyphoplasty, Length of Stay, Male, Models, Econometric, Osteoporotic Fractures, Quality of Life, Spinal Fractures
Abstract
SUMMARY: Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients. INTRODUCTION: VCFs of osteoporotic patients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial. METHODS: The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management. RESULTS: The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at 8,800 pound sterling. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits. CONCLUSION: In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting.
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