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Publication Detail
Magnetically assisted delivery of cells using a magnetic resonance imaging system
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Riegler J, Allain B, Cook RJ, Lythgoe MF, Pankhurst QA
  • Publisher:
    IOP PUBLISHING LTD
  • Publication date:
    09/02/2011
  • Journal:
    J PHYS D APPL PHYS
  • Volume:
    44
  • Issue:
    5
  • Print ISSN:
    0022-3727
  • Language:
    EN
  • Keywords:
    CLINICAL-TRIAL, NANOPARTICLES, INFARCTION
  • Addresses:
    Riegler, J
    UCL
    Ctr Adv Biomed Imaging
    Dept Med
    London
    WC1E 6DD
    England

    UCL
    Inst Child Hlth
    London
    WC1E 6DD
    England
Abstract
A simple analytical model is presented which enables rapid interactive prediction and control of magnetically labelled cells in an arterial bifurcation using magnetic field gradients produced by a magnetic resonance imaging (MRI) system. This model is compared against experimental results for human mononuclear cells labelled with micrometre sized superparamagnetic iron oxide particles. Experimental and theoretical results highlight the importance of cell aggregation for magnetic targeting in a strong magnetic field. These predicted aggregates are confirmed via confocal endoscopy which allows the visualization of cell aggregates and their movement inside a vascular flow model in a 9.4 T preclinical MRI scanner.
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