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Publication Detail
Axon diameter mapping in the presence of orientation dispersion using diffusion MRI
  • Publication Type:
  • Authors:
    ZHANG H, Hubbard PL, Parker GJM, Alexander DC
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  • Publication date:
  • Place of publication:
    Berkeley, US
  • Pagination:
  • Published proceedings:
    Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM 2011): 19th Annual Meeting and Exhibition
  • Volume:
  • Editors:
    Abbott DF,Ackermann JH
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  • Print ISSN:
  • Language:
  • Keywords:
    Axon diameter, diffusion MRI, orientation dispersion
Axon diameter mapping using diffusion MRI provides more specific biomarkers than DTI indices. Earlier works assume a model of strictly parallel axons. However, such approximation is inadequate for most white matter regions in which axons fan or bend, resulting in significant orientation dispersion. Such dispersion, if unaccounted for, leads to overestimation of axon diameters. We ameliorates this problem by proposing a model that captures orientation dispersion explicitly. We demonstrate that recovery of axon diameters is possible even in the presence of orientation dispersion, supporting accurate axon diameter mapping in a much wider set of white matter than previously possible
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