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Publication Detail
p185, an immunodominant epitope, is an autoantigen mimotope.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Kumar S, Hinks JA, Maman J, Ravirajan CT, Pearl LH, Isenberg DA
  • Publication date:
  • Pagination:
    26220, 26227
  • Journal:
    J Biol Chem
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • PII:
  • Language:
  • Keywords:
    Adult, Amino Acid Sequence, Animals, Autoantigens, Base Sequence, DNA, DNA-Binding Proteins, Female, Humans, Immunodominant Epitopes, Lupus Erythematosus, Systemic, Male, Mice, Molecular Sequence Data, Peptide Fragments, Receptor, ErbB-2
An immunodominant peptide (p185(378-394)) derived from the c-erbB2 gene product, was recognized by an anti-DNA antibody, B3, and importantly by two classical DNA-binding proteins, Tgo polymerase and Pa-UDG. These reactivities were inhibited by DNA, confirming that the peptide mimicked DNA. BALB/c mice immunized with p185(378-394) developed significant titers of IgG anti-dsDNA antibodies. Screening of 39 human lupus sera revealed that 5% of these sera possessed reactivity toward p185(378-394). Representative mouse and human sera with anti-p185(378-394) reactivity bound intact p185, and this binding was inhibited by dsDNA. This is the first demonstration of a naturally occurring autoantigen mimotope. The present study identifies a potential antigenic stimulus that might trigger systemic lupus erythematosus in a subset of patients.
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