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Publication Detail
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Schioppa T, Moore R, Thompson RG, Rosser EC, Kulbe H, Nedospasov S, Mauri C, Coussens LM, Balkwill FR
  • Publication date:
    28/06/2011
  • Pagination:
    10662, 10667
  • Journal:
    Proc Natl Acad Sci U S A
  • Volume:
    108
  • Issue:
    26
  • Status:
    Published
  • Country:
    United States
  • PII:
    1100994108
  • Language:
    eng
  • Keywords:
    9,10-Dimethyl-1,2-benzanthracene, Adoptive Transfer, Animals, B-Lymphocytes, Carcinogens, Carcinoma, Squamous Cell, Immunohistochemistry, Mice, Mice, Knockout, Skin Neoplasms, Tumor Necrosis Factor-alpha
Abstract
The inflammatory cytokine TNF-α has been recognized as a critical tumor promoter, but the effector cells that mediate its action have not been fully characterized. Because B cells regulate squamous and prostate carcinogenesis, and Tnf(-/-) mice harbor B-cell defects, we investigated the hypothesis that B cells are important effector cells for TNF-α-mediated promotion of cancer development. Using an adoptive transfer strategy and the 7,12-dimethylbenz[α]anthracene/terephthalic acid (DMBA/TPA) two-stage model of skin carcinogenesis, we found that both B cells and TNF-α are critical for the development of DMBA/TPA-induced papilloma. Transfer of B cells from DMBA/TPA-treated wild-type mice to Tnf(-/-) mice rescued papilloma development to a wild-type level, a result not observed when B cells from Tnf(-/-) mice were transferred to Rag2(-/-) mice or when TNF-α was eliminated selectively in B cells. Resistance to papilloma development in Tnf(-/-) mice was associated with increased IFN-γ and CD8(+) T cells in skin and a significant reduction in IL-10-producing B regulatory cells alongside an increase in IFN-γ-producing CD8(+) T cells in the spleen. These data indicate that during DMBA/TPA-induced squamous carcinogenesis TNF-α mediates tumor-promoting activity via regulatory B cells that repress antitumor immunity.
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