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Publication Detail
Bio-electrosprayed living composite matrix implanted into mouse models.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jayasinghe SN, Warnes G, Scotton CJ
  • Publication date:
    10/10/2011
  • Pagination:
    1364, 1369
  • Journal:
    Macromol Biosci
  • Volume:
    11
  • Issue:
    10
  • Country:
    Germany
  • Language:
    eng
  • Keywords:
    Animals, Annexin A5, Biocompatible Materials, Cell Survival, Fibroblasts, Flow Cytometry, Lung, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Models, Animal, Phenotype, Propidium, Prostheses and Implants, Subcutaneous Tissue, Tissue Engineering, Tissue Scaffolds
Abstract
We show that composite de novo structures can be generated using bio-electrosprays. Mouse lung fibroblasts are bio-electrosprayed directly with a biopolymer to form cell-bearing matrices, which are viable even when implanted subcutaneously into murine hosts. Generated cell-bearing matrices are assessed in-vitro and found to undergo all expected cellular behaviour. Subsequent in-vivo studies demonstrate the implanted living matrices integrating as expected with the surrounding microenvironment. The in-vitro and in-vivo studies elucidate and validate the ability for either bio-electrosprays or cell electrospinning to form a desired living architecture for undergoing investigation for repairing, replacing and rejuvenating damaged and/or ageing tissues.
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