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Publication Detail
Electrohydrodynamic preparation of particles, capsules and bubbles for biomedical engineering applications
  • Publication Type:
    Conference
  • Authors:
    Enayati M, Chang MW, Bragman F, Edirisinghe M, Stride E
  • Publisher:
    ELSEVIER SCIENCE BV
  • Publication date:
    05/06/2011
  • Pagination:
    154, 164
  • Published proceedings:
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
  • Volume:
    382
  • Issue:
    1-3
  • Name of conference:
    8th EUFOAM Conference/Meeting on COST Actions D43 and P21
  • Conference place:
    Borovets, BULGARIA
  • Conference start date:
    13/07/2010
  • Conference finish date:
    16/07/2010
  • Print ISSN:
    0927-7757
  • Language:
    EN
  • Keywords:
    Particles, Bubbles, Capsules, Electrohydrodynamic, Biomedical, Drug delivery, Electrospraying, Electrospinning, BIODEGRADABLE POLYMERIC MICROSPHERES, BOVINE SERUM-ALBUMIN, CONE-JET MODE, DRUG-DELIVERY, SOLVENT EXTRACTION/EVAPORATION, ELECTROSPRAY ENCAPSULATION, DYNAMIC ATOMIZATION, PROTEIN DRUGS, TAYLOR CONES, LIQUID CONE
  • Addresses:
    Stride, E
    UCL
    Dept Mech Engn
    London
    WC1E 7JE
    England
Abstract
Electrohydrodynamic (EHD) processing is a method of generating liquid droplets through the application of a large electrical potential difference. It has a wide range of applications in both industrial processes and analytical instrumentation. Research carried out over the last decade has greatly increased the capabilities of END processing, providing the capability to coat, print, spin, thread, bubble or encapsulate a wide variety of materials.One of the reasons interest in END processing has escalated in recent years is due to its ability to prepare structures at the micro and nano scales. This review paper focuses on the biomedical applications of the various products, especially in drug delivery, and considers the latest achievements in micro- and nano-carrier production. A brief description of the basic physical principles underlying the process is provided and the range of experimental configurations, from single to multi-needle coaxial processing, is examined, together with the resulting structures. Finally the applications of EHD processing and its products are considered, demonstrating its potential, not only for particle and fibre formation, but as a powerful technique for the encapsulation of bioactive materials such as proteins, enzymes, antibiotics and DNA fragments in polymeric particles. (C) 2010 Elsevier B.V. All rights reserved.
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Dept of Mechanical Engineering
Dept of Mechanical Engineering
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