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Publication Detail
Antiphospholipid syndrome
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Manson JJ, Isenberg DA
  • Publication date:
    07/2003
  • Pagination:
    1015, 1020
  • Journal:
    The International Journal of Biochemistry and Cell Biology
  • Volume:
    35
  • Issue:
    7
  • Print ISSN:
    1357-2725
  • Keywords:
    abnormal, Adhesion, adhesion molecule, Adhesion molecules, aggregation, Animals, annexin, Annexin V, antibodies, Antibodies, Antiphospholipid, Antibody, Anticoagulant, Anticoagulants, antiphospholipid, Antiphospholipid Syndrome, aPL, apoptosis, Arterial, As, Aspirin, BINDING, BINDING-PROTEIN, cell, Cell Adhesion, cell adhesion molecules, development, disease, Disruption, drug therapy, DYSFUNCTION, endogenous, Endothelial, endothelial cell, Endothelium, Vascular, EXPOSURE, IM, immunology, LA, lipid, Lipid Peroxidation, LIPID-PEROXIDATION, May, membrane, miscarriage, model, MODELS, MOLECULES, novel, PATHOGENESIS, Platelet, Platelet Aggregation, process, processes, PROTEIN, Proteins, RECURRENT, Research, Review, Syndrome, therapeutic use, therapy, treatment, Up-Regulation, Venous, Warfarin
  • Notes:
    DA - 20030403 IS - 1357-2725 LA - eng PT - Journal Article PT - Review PT - Review, Tutorial RN - 0 (Annexin V) RN - 0 (Antibodies, Antiphospholipid) RN - 0 (Anticoagulants) RN - 81-81-2 (Warfarin) SB - IM
Abstract
Antiphospholipid syndrome (APS) is defined as the presence of venous or arterial thromboses, and/or recurrent miscarriage, with evidence of antiphospholipid antibodies (aPL). Central to the disease, is the development of the antibodies to phospholipid molecules themselves, or to their binding proteins. The production of these antibodies may depend upon the unusual exposure of cytoplasmic molecules seen during the process of apoptosis. The exact pathogenesis of antiphospholipid syndrome remains unclear, but various putative models exist. These include the up-regulation of endothelial cell adhesion molecules, membrane disruption during lipid peroxidation, a dysfunction of endogenous anticoagulants, or abnormal platelet aggregation. The mainstay of treatment is with aspirin or warfarin, and more research is required to discover novel, and safer, therapies
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