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Publication Detail
Antimicrobial activity of polyurethane embedded with methylene blue, toluidene blue and gold nanoparticles against Staphylococcus aureus; illuminated with white light
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Naik AJT, Ismail S, Kay C, Wilson M, Parkin IP
  • Publisher:
    ELSEVIER SCIENCE SA
  • Publication date:
    15/09/2011
  • Pagination:
    446, 450
  • Journal:
    MATER CHEM PHYS
  • Volume:
    129
  • Issue:
    1-2
  • Print ISSN:
    0254-0584
  • Language:
    EN
  • Keywords:
    Polymer, Biomaterial, Antimicrobial, Methylene blue, Toluidene blue, Nanogold, CATHETER-RELATED INFECTIONS, GRAM-NEGATIVE BACTERIA, PHOTODYNAMIC THERAPY, BLOOD COMPONENTS, LETHAL PHOTOSENSITIZATION, MICROBIAL INFECTIONS, SINGLET OXYGEN, PHOTODECONTAMINATION, INACTIVATION, PREVENTION
  • Addresses:
    Parkin, IP
    UCL
    Mat Chem Res Ctr
    Dept Chem
    London
    WC1H OAJ
    England
Abstract
Polyurethane polymer sheets were embedded with methylene blue (MB), toluidine blue (TBO) and 2 nm gold nanoparticles by a swell-shrink encapsulation process using an acetone water mixture. The polymers were characterised by IR, UV-vis, SEM/WDX and mechanical testing. The dye impregnated polymers were potent at killing suspensions of Staphylococcus aureus under white illumination with a hospital light source (2000 lux) showing a 2.8 log(10) kill (MB) and a 4.3 log(10) kill (TBO) compared to controls when exposed to 24 h of illumination. Notably the incorporation of gold nanoparticles with the dyes enhanced the observed kill to 3.8 log(10) (MB) and 4.8 log(10) (TBO). This is the first time that a derivatised polyurethane polymer used in catheters has been shown to be effective in killing bacteria using white light illumination. (C) 2011 Elsevier B.V. All rights reserved.
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Structural & Molecular Biology
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Dept of Chemistry
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Microbial Diseases
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