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Publication Detail
Prevention of arthritis by interleukin 10-producing B cells
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Mauri C, Gray D, Mushtaq N, Londei M
  • Publication date:
    17/02/2003
  • Pagination:
    489, 501
  • Journal:
    Journal of Experimental Medicine
  • Volume:
    197
  • Issue:
    4
  • Print ISSN:
    0022-1007
  • Keywords:
    *Adoptive Transfer Animals Arthritis/*prevention & control B-Lymphocytes/*physiology CD4-Positive T-Lymphocytes/physiology Collagen Type II/immunology Interferon Type II/biosynthesis Interleukin-10/*physiology Mice Mice, Inbred DBA Support, Non-U.S.Gov't, ACTIVATION, Adjuvant, ANTIGEN, Arthritis, As, autoimmune, B CELL, B CELLS, B-cell, B-CELLS, cell, Cell Differentiation, CELLS, Collagen, Complete, developing, development, differentiation, disease, DISORDER, Disorders, function, IB, in vitro, In-vitro, INTERFERON, knockout, LEVEL, Low, mice, population, Prevention, Result, T cell, T-CELL, TYPE-1, unit, VITRO
  • Notes:
    12591906 0022-1007 Journal Article IB Unit
Abstract
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-gamma. Transfer of these B cells into DBA/1-TcR-beta-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease. IL-10 is essential for the regulatory function of this subset of B cells, as the B cells population isolated from IL-10 knockout mice failed to mediate this protective function. Furthermore, B cells isolated from arthritogenic splenocytes treated in vitro with anti-IL-10/anti-IL-10R were unable to protect recipient mice from developing arthritis. Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders
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