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Publication Detail
New role for Agrin in T cells and its potential importance in immune system regulation
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    Jury EC, Kabouridis PS
  • Publication date:
    12/04/2010
  • Journal:
    Arthritis Research and Therapy
  • Volume:
    12
  • Issue:
    2
  • Status:
    Published
  • Print ISSN:
    1478-6354
Abstract
Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system. © 2010 BioMed Central Ltd.
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