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Publication Detail
Lipid rafts and T-lymphocyte function: Implications for autoimmunity
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Short Survey
  • Authors:
    Kabouridis PS, Jury EC
  • Publication date:
    12/11/2008
  • Pagination:
    3711, 3718
  • Journal:
    FEBS Letters
  • Volume:
    582
  • Issue:
    27
  • Status:
    Published
  • Print ISSN:
    0014-5793
Abstract
Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T-lymphocytes, lipid rafts are implicated in signalling from the T-cell antigen receptor (TCR) and in localization and function of proteins residing proximal to the receptor. This review summarizes the current literature that deals with lipid raft involvement in T-cell activation and places particular emphasis in recent studies investigating lipid rafts in autoimmunity. The potential of lipid rafts as targets for the development of a new class of immune-modulating compounds is discussed. © 2008 Federation of European Biochemical Societies.
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