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Publication Detail
T-lymphocyte signalling in systemic lupus erythematosus: A lipid raft perspective
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Jury EC, Kabouridis PS
  • Publication date:
  • Pagination:
    413, 422
  • Journal:
  • Volume:
  • Issue:
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  • Print ISSN:
In the last few years it has become clear that in cells of the immune system, specialized microdomains present in the plasma membrane, called lipid rafts, have been found to play a central role in regulating signalling by immune receptors. Recent studies have looked at whether lipid rafts may be connected to the abnormalities in signalling seen in T lymphocytes isolated from patients with systemic lupus erythematosus (SLE). These early findings show that in SLE T cells, the expression and protein composition of lipid rafts is different when compared with normal T cells. These results also demonstrate changes in the function and localization of critical signalling molecules such as the LCK tyrosine kinase and the CD45 tyrosine phosphatase.
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