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Publication Detail
Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Chavele K-M, Ehrenstein MR
  • Publication date:
    01/12/2011
  • Pagination:
    3603, 3610
  • Journal:
    FEBS Lett
  • Volume:
    585
  • Issue:
    23
  • Status:
    Published
  • Country:
    England
  • PII:
    S0014-5793(11)00572-2
  • Language:
    eng
  • Keywords:
    Animals, Arthritis, Rheumatoid, Disease Models, Animal, Humans, Lupus Erythematosus, Systemic, Models, Immunological, T-Lymphocytes, Regulatory
Abstract
Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA.
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