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Publication Detail
Therapeutic potential of Tregs to treat rheumatoid arthritis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Wright GP, Stauss HJ, Ehrenstein MR
  • Publication date:
    06/2011
  • Pagination:
    195, 201
  • Journal:
    Semin Immunol
  • Volume:
    23
  • Issue:
    3
  • Status:
    Published
  • Country:
    England
  • PII:
    S1044-5323(11)00060-1
  • Language:
    eng
  • Keywords:
    Animals, Arthritis, Rheumatoid, Humans, Immunotherapy, Self Tolerance, T-Lymphocytes, Regulatory
Abstract
There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there are a number of approaches currently being developed to utilise their potent immunosuppressive properties. Through genetic manipulation Tregs can be generated ex vivo or in vivo that target antigens present in the inflamed joint. Here we discuss these approaches, their refinement to restore tolerance in patients with rheumatoid arthritis, and strategies to prevent their conversion towards a Th17 phenotype.
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