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Publication Detail
Effects of respiratory liver motion on heating for gated and model-based motion-compensated high-intensity focused ultrasound ablation.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Rijkhorst E-J, Rivens I, Haar GT, Hawkes D, Barratt D
  • Publication date:
    2011
  • Pagination:
    605, 612
  • Journal:
    Med Image Comput Comput Assist Interv
  • Volume:
    14
  • Issue:
    Pt 1
  • Status:
    Published
  • Country:
    Germany
  • Language:
    eng
  • Keywords:
    Abdomen, Algorithms, Burns, Computer Simulation, Heating, Hot Temperature, Humans, Imaging, Three-Dimensional, Liver, Magnetic Resonance Imaging, Motion, Respiration, Skin, Temperature, Time Factors
Abstract
PURPOSE: To quantify the effects of respiratory motion on high-intensity focused ultrasound heating of liver tissue by comparing the simulated ablation using a conventional respiratory gating versus a MR-model-based motion compensation approach. METHODS: To measure liver motion, dynamic free-breathing abdominal MR scans were acquired for five volunteers. Deformable registration was used to calculate continuous motion models, and tissue heating at a moving single focus was computed in 3-D by solving the bioheat equation. Ablated volume ratios with respect to the static case, V(ab), were determined for a range of exposure times t(exp) and heating rates r. RESULTS: To achieve V(ab) > 90% required t(exp) < 0.5s and r > 120 degrees C/s when gating, whereas t(exp) < 1s and r > 60 degrees C/s for motion-compensation. CONCLUSIONS: Accurate compensation for respiratory motion is important for efficient tissue ablation. Model-based motion compensation allows substantially lower heating rates than gating, reducing the risk of skin burns and focal boiling.
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