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Publication Detail
Androgens affect myogenesis in vitro and increase local IGF-1 expression.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Sculthorpe N, Solomon AM, Sinanan AC, Bouloux PM, Grace F, Lewis MP
  • Publication date:
    04/2012
  • Pagination:
    610, 615
  • Journal:
    Med Sci Sports Exerc
  • Volume:
    44
  • Issue:
    4
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    Adolescent, Adult, Androgen Receptor Antagonists, Cells, Cultured, Flutamide, Humans, Insulin-Like Growth Factor I, Male, Muscle Development, Muscle, Skeletal, Receptors, Androgen, Testosterone, Young Adult
Abstract
The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.
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