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Publication Detail
The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA
  • Publication Type:
    Journal article
  • Publication Sub Type:
    article
  • Authors:
    Harrison AP, Rowsell J, Camargo RDS, Langdon WB, Stalteri M, Upton GJG, Arteaga-Salas JM
  • Publication date:
    2008
  • Pagination:
    511, 513
  • Journal:
    Biochemical Society Transactions
  • Volume:
    36
  • Notes:
    keywords: Affymetrix GeneChip, alternative polyadenylation, alternative splicing, microarray, post-transcriptional processing, RNA size: 3 pages
Abstract
We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
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