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Publication Detail
Parkinson's disease and cancer: two wars, one front.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Devine MJ, Plun-Favreau H, Wood NW
  • Publication date:
    24/10/2011
  • Pagination:
    812, 823
  • Journal:
    Nat Rev Cancer
  • Volume:
    11
  • Issue:
    11
  • Status:
    Published online
  • Country:
    England
  • PII:
    nrc3150
  • Language:
    eng
  • Keywords:
    Animals, Cell Cycle Checkpoints, DNA Repair, Gaucher Disease, Humans, Mitochondria, Neoplasms, Oxidative Stress, Parkinson Disease, Protein Folding, Proteostasis Deficiencies, Signal Transduction
Abstract
Parkinson's disease is caused by the premature death of neurons in the midbrain. By contrast, cancer spawns from cells that refuse to die. We would therefore expect their pathogenic mechanisms to be very different. However, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in both diseases. We consider these areas of convergence and discuss how insights from one disease can inform us about, and possibly help us to treat, the other.
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