UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The role played by the interaction between genetic factors and attachment in the stress response in infancy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Frigerio A, Ceppi E, Rusconi M, Giorda R, Raggi ME, Fearon P
  • Publication date:
    12/2009
  • Pagination:
    1513, 1522
  • Journal:
    J Child Psychol Psychiatry
  • Volume:
    50
  • Issue:
    12
  • Status:
    Published
  • Country:
    England
  • PII:
    JCPP2126
  • Language:
    eng
  • Keywords:
    Adult, Alleles, Child, Preschool, Family, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Male, Mother-Child Relations, Object Attachment, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Dopamine D4, Receptors, GABA-A, Salivary Glands, Serotonin Plasma Membrane Transport Proteins, Stress, Psychological, alpha-Amylases
Abstract
BACKGROUND: The importance of understanding which environmental and biological factors are involved in determining individual differences in physiological response to stress is widely recognized, given the impact that stress has on physical and mental health. METHODS: The child-mother attachment relationship and some genetic polymorphisms (5-HTTLPR, COMT and GABRA6) were tested as predictors of salivary cortisol and alpha amylase concentrations, two biomarkers of hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic adrenomedullary (SAM) system activity, during the Strange Situation (SS) procedure in a sample of more than 100 healthy infants, aged 12 to 18 months. RESULTS: Individual differences in alpha amylase response to separation were predicted by security of attachment in interaction with 5-HTTLPR and GABRA6 genetic polymorphisms, whereas alpha amylase basal levels were predicted by COMT x attachment interaction. No significant effect of attachment, genetics and their interaction on cortisol activity emerged. CONCLUSIONS: These results help to disentangle the role played by both genetic and environmental factors in determining individual differences in stress response in infancy. The results also shed light on the suggestion that HPA and SAM systems are likely to have different characteristic responses to stress.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical, Edu & Hlth Psychology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by