UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
An introduction to induced pluripotent stem cells
  • Publication Type:
    Journal article
  • Publication Sub Type:
    JOUR
  • Authors:
    Hanley J, Rastegarlari G, Nathwani AC
  • Publication date:
    10/2010
  • Pagination:
    16, 24
  • Journal:
    Br.J.Haematol.
  • Volume:
    151
  • Issue:
    1
  • Keywords:
    Animals, Cell Differentiation, cytology, Drug Evaluation,Preclinical, Embryo Research, Embryonic Stem Cells, ethics, Humans, Induced Pluripotent Stem Cells, methods, Mice, Nuclear Reprogramming, transplantation
  • Author URL:
  • Notes:
    DA - 20101005 IS - 1365-2141 (Electronic) IS - 0007-1048 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review SB - IM
Abstract
Recent landmark studies show that it is now possible to convert somatic cells, such as skin fibroblasts and B lymphocytes, into pluripotent stem cells that closely resemble embryonic stem cells. These induced pluripotent stem (iPS) cells can be generated without using human embryos or oocytes, thus bypassing some of the ethical issues that have limited the use of human embryonic stems (hES) cells. Additionally, they can be derived from the patient to be treated, thereby overcoming problems of immunological rejection associated with the use of allogeneic hES cell derived progenitors. Whilst these patient-specific iPS cells have great clinical potential, their immediate utility is likely to be in drug screening and for understanding the disease process. This review discusses the promise of iPS cells as well as the challenges to their use in the clinic
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Research Department of Haematology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by