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Publication Detail
Early treatment with rituximab in newly diagnosed systemic lupus erythematosus patients: a steroid-sparing regimen.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Comparative Study
  • Authors:
    Ezeonyeji AN, Isenberg DA
  • Publication date:
    03/2012
  • Pagination:
    476, 481
  • Journal:
    Rheumatology (Oxford)
  • Volume:
    51
  • Issue:
    3
  • Status:
    Published
  • Country:
    England
  • PII:
    ker337
  • Language:
    eng
  • Keywords:
    Adrenal Cortex Hormones, Adult, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Murine-Derived, Antirheumatic Agents, Azathioprine, B-Lymphocytes, Blood Sedimentation, Case-Control Studies, Complement C3, Cyclophosphamide, DNA, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Lupus Erythematosus, Systemic, Lymphocyte Depletion, Middle Aged, Prednisolone, Rituximab, Severity of Illness Index, Treatment Outcome, Young Adult
Abstract
OBJECTIVES: To assess the effectiveness of B-cell depletion therapy (BCDT) as a steroid-sparing treatment in newly diagnosed SLE patients. METHODS: Eight female SLE patients were treated with BCDT using a rituximab/CYC-based regimen aiming to avoid the routine use of oral steroids. Post-treatment, patients were given AZA. The BILAG disease activity index was used for clinical assessment. Serum anti-dsDNA, complement (C3), ESR, circulating B lymphocytes (CD19(+)) and protein : creatinine ratio were tested at 0, 1, 3, 6 and 12 months post-treatment. Disease activity and steroid requirement over the first 6 months of treatment were compared with three SLE patients treated conventionally, each carefully matched for ethnicity, sex, age at disease onset and disease duration at diagnosis. RESULTS: All patients achieved B-cell depletion (CD19 count <0.005 × 10(9)/l). The mean decrease in global BILAG at 6 months for the BCDT patients was -12.0 vs 13.22 for the controls. Post-BCDT, no patient developed any significant deterioration, mean ESR fell from 70.12 to 17.14 mm/h at 6 months, mean serum anti-dsDNA antibody levels fell by >70% at 1 month and serum C3 level normalized in two patients by 6 months. There were no adverse events. The mean cumulative prednisolone dose at 6 months for the BCDT patients was 1287.3 mg (range 250-4501.8 mg) vs 2834.6 mg (range 0-6802.5 mg) for the controls. CONCLUSION: Early treatment of SLE patients with BCDT is safe and effective and enables a reduction in the overall steroid burden.
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