UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
New and unusual scaffolds in medicinal chemistry
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    Marson CM
  • Publisher:
    ROYAL SOC CHEMISTRY
  • Publication date:
    2011
  • Pagination:
    5514, 5533
  • Journal:
    CHEM SOC REV
  • Volume:
    40
  • Issue:
    11
  • Print ISSN:
    0306-0012
  • Language:
    EN
  • Keywords:
    GAMMA-SECRETASE INHIBITORS, HCV NS3 PROTEASE, SELECTIVE BUTYRYLCHOLINESTERASE INHIBITORS, POTENT 11-BETA-HSD1 INHIBITORS, HISTONE DEACETYLASE INHIBITOR, D-3 RECEPTOR ANTAGONISTS, BIOLOGICAL EVALUATION, DRUG DISCOVERY, IN-VIVO, BINDING-AFFINITY
  • Addresses:
    UCL
    Dept Chem
    Christopher Ingold Labs
    London
    WC1H 0AJ
    England
Abstract
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent; the increasingly demanding requirements of low toxicity shown across all patients treated; and the need for novelty in intellectual property, given the extensive use of benzenoid and heteroaromatic ring systems in numerous patents. Increasingly, such challenges are being met by a shift to new and/or unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems. This critical review surveys a necessarily limited selection of currently atypical scaffolds, chiefly drawn from the literature of the last three years, that have found application in medicinal chemistry, some being present in agents with therapeutic potential while others are found in agents already in clinical use (163 references).
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by