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Publication Detail
Molecular biology and physiology of glutamate transporters
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bouvier M, Amato A, Attwell D
  • Publication date:
    01/01/1994
  • Pagination:
    117, 125
  • Journal:
    Seminars in the Neurosciences
  • Volume:
    6
  • Issue:
    2
  • Status:
    Published
  • Print ISSN:
    1044-5765
Abstract
Amino acid transporters in neurons and glia prevent the extracellular concentration of L-glutamate rising to neurotoxic levels, and at some synapses may help to terminate neurotransmitter action. Here we review recent advances in our understanding of the molecular biology and physiology of glutamate uptake carriers, focusing on the molecular structure of the carriers cloned to date, on the stoichiometry of the uptake process, on the localization of the carriers and their role in synaptic transmission, and on how the rate of uptake might be modulated physiologically and in neurological disorders. © 1994 Academic Press. All rights reserved.
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