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Publication Detail
Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Setting, degradation and drug release considerations
Abstract
This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-copropylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity. © Springer Science+Business Media, LLC 2011.
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UCL Authors
Biomaterials & Tissue Eng
Eastman Dental Institute
Biomaterials & Tissue Eng
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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