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Publication Detail
Accurate localisation of optic radiation during neurosurgery in an interventional MRI Suite
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Daga P, Winston G, Modat M, White M, Mancini L, Cardoso M, Symms M, Hawkes D, Duncan J, Ourselin S
  • Publication date:
  • Journal:
    IEEE Trans Med Imaging
Accurate localisation of the optic radiation is key to improving the surgical outcome for patients undergoing anterior temporal lobe resection for the treatment of refractory focal epilepsy. Current commercial interventional MRI scanners are capable of performing anatomical and diffusion weighted imaging and are used for guidance during various neurosurgical procedures. We present an interventional imaging workflow that can accurately localise the optic radiation during surgery. The workflow is driven by a near real-time multichannel nonrigid image registration algorithm that uses both anatomical and fractional anisotropy pre- and intra-operative images. The proposed workflow is implemented on graphical processing units and we perform a warping of the pre-operatively parcellated optic radiation to the intra-operative space in under three minutes making the proposed algorithm suitable for use under the stringent time constraints of neurosurgical procedures. The method was validated using both a numerical phantom and clinical data using pre- and post-operative images from patients who had undergone surgery for treatment of refractory focal epilepsy and shows strong correlation between the observed postoperative visual field deficit and the predicted damage to the optic radiation. We also validate the algorithm using interventional MRI datasets from a small cohort of patients. This work could be of significant utility in image guided interventions and facilitate effective surgical treatments.
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Clinical & Experimental Epilepsy
Dept of Med Phys & Biomedical Eng
Dept of Med Phys & Biomedical Eng
UCL Queen Square Institute of Neurology
Div of Medicine
UCL Queen Square Institute of Neurology
Brain Repair & Rehabilitation
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