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Publication Detail
The signaling protein CD38 is essential for early embryonic development.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Churamani D, Geach TJ, Ramakrishnan L, Prideaux N, Patel S, Dale L
  • Publication date:
    02/03/2012
  • Pagination:
    6974, 6978
  • Journal:
    J Biol Chem
  • Volume:
    287
  • Issue:
    10
  • Status:
    Published
  • Country:
    United States
  • PII:
    S0021-9258(20)61016-X
  • Language:
    eng
  • Keywords:
    ADP-ribosyl Cyclase 1, Animals, Calcium, Calcium Signaling, Cell Differentiation, Embryo, Nonmammalian, Embryonic Development, Gene Expression Regulation, Developmental, Muscle, Skeletal, Xenopus laevis
Abstract
CD38 is a multifunctional protein possessing ADP-ribosyl cyclase activity responsible for both the synthesis and the degradation of several Ca(2+)-mobilizing second messengers. Although a variety of functions have been ascribed to CD38, such as immune responses, insulin secretion, and social behavior in adults, nothing is known of its role during embryonic development when Ca(2+) signals feature prominently. Here, we report the identification and functional expression of CD38 from Xenopus laevis, a key model organism for the study of vertebrate development. We show that CD38 expression and endogenous ADP-ribosyl cyclase activity are developmentally regulated during cellular differentiation. Chemical or molecular inhibition of CD38 abolished ADP-ribosyl cyclase activity and disrupted elongation of the anterior-posterior axis and differentiation of skeletal muscle, culminating in embryonic death. Our data uncover a previously unknown role for CD38 as an essential regulator of embryonic development.
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