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Publication Detail
A composite computational model of liver glucose homeostasis. II. Exploring system behaviour.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Sumner T, Hetherington J, Seymour RM, Li L, Varela Rey M, Yamaji S, Saffrey P, Margoninski O, Bogle IDL, Finkelstein A, Warner A
  • Publication date:
    07/04/2012
  • Pagination:
    701, 706
  • Journal:
    J R Soc Interface
  • Volume:
    9
  • Issue:
    69
  • Status:
    Published
  • Country:
    England
  • PII:
    rsif.2011.0783
  • Language:
    eng
  • Keywords:
    Activity Cycles, Blood Glucose, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Liver, Models, Biological, Systems Biology
Abstract
Using a composite model of the glucose homeostasis system, consisting of seven interconnected submodels, we enumerate the possible behaviours of the model in response to variation of liver insulin sensitivity and dietary glucose variability. The model can reproduce published experimental manipulations of the glucose homeostasis system and clearly illustrates several important properties of glucose homeostasis-boundedness in model parameters of the region of efficient homeostasis, existence of an insulin sensitivity that allows effective homeostatic control and the importance of transient and oscillatory behaviour in characterizing homeostatic failure. Bifurcation analysis shows that the appearance of a stable limit cycle can be identified.
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