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Publication Detail
Tau acts as an independent genetic risk factor in pathologically proven PD
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Charlesworth G, Gandhi S, Bras JM, Barker RA, Burn DJ, Chinnery PF, Gentleman SM, Guerreiro R, Hardy J, Holton JL, Lees A, Morrison K, Sheerin UM, Williams N, Morris H, Revesz T, Wood NW
  • Publication date:
    01/04/2012
  • Journal:
    Neurobiology of Aging
  • Volume:
    33
  • Issue:
    4
  • Status:
    Published
  • Print ISSN:
    0197-4580
Abstract
MAPT has been repeatedly linked with Parkinson's disease (PD) in association studies. Although tau deposition may be seen in PD, its relevance to the pathogenesis of the condition remains unclear. The presence of tau-positive inclusions is, however, the defining feature of progressive supranuclear palsy (PSP), which may often be clinically misdiagnosed as idiopathic PD. On a genetic level, variants in MAPT are the strongest risk factor for PSP. These facts raise the question whether the MAPT association in PD results from contamination with unrecognized cases of PSP. Using only neuropathologically proven PD, we show that the MAPT association remains and is independent of the PSP Association. © 2012 Elsevier Inc.
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