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Publication Detail
Lipid-antigen presentation by CD1d(+) B cells is essential for the maintenance of invariant natural killer T cells.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bosma A, Abdel-Gadir A, Isenberg DA, Jury EC, Mauri C
  • Publication date:
    23/03/2012
  • Pagination:
    477, 490
  • Journal:
    Immunity
  • Volume:
    36
  • Issue:
    3
  • Status:
    Published
  • Country:
    United States
  • PII:
    S1074-7613(12)00081-7
  • Language:
    eng
  • Keywords:
    Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Murine-Derived, Antigen Presentation, Antigens, CD1d, B-Lymphocytes, Case-Control Studies, Cell Differentiation, Cell Proliferation, Cytokines, Female, Humans, Immunosuppressive Agents, Lipids, Lupus Erythematosus, Systemic, Lymphocyte Activation, Lymphocyte Count, Male, Middle Aged, Natural Killer T-Cells, Rituximab, Young Adult
Abstract
B cells perform many immunological functions, including presenting lipid antigen to CD1d-restricted invariant natural killer T (iNKT) cells, known to contribute to maintaining tolerance in autoimmunity. Patients with systemic lupus erythematous (SLE) display dysregulated B cell responses and reduced peripheral iNKT cell frequencies. The significance of these defects and how they relate to SLE pathogenesis remain elusive. We report that B cells are essential for iNKT cell expansion and activation in healthy donors but fail to exert a similar effect in SLE patients. Defective B cell-mediated stimulation of iNKT cells in SLE patients was associated with altered CD1d recycling, a defect recapitulated in B cells from healthy donors after stimulation with interferon-α (IFN-α) and anti-immunoglobulin (Ig). iNKT cell number and function were restored in SLE patients responding to anti-CD20 treatment upon normalization of CD1d expression exclusively in repopulated immature B cells. We propose that healthy B cells are pivotal for iNKT cell homeostasis.
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