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Publication Detail
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF
  • Publication date:
    07/04/2006
  • Pagination:
    75, 79
  • Journal:
    Science
  • Volume:
    312
  • Issue:
    5770
  • Country:
    United States
  • PII:
    1122689
  • Language:
    eng
  • Keywords:
    3' Untranslated Regions, Adenosine, Animals, Embryo, Nonmammalian, Embryonic Development, Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Genes, Reporter, Green Fluorescent Proteins, MicroRNAs, Mutation, Oligonucleotide Array Sequence Analysis, Polymers, Protein Biosynthesis, RNA Stability, RNA, Messenger, Ribonuclease III, Transcription, Genetic, Up-Regulation, Zebrafish, Zygote
Abstract
MicroRNAs (miRNAs) comprise 1 to 3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. By using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target messenger RNA molecules (mRNAs). Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.
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