UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
OFF ganglion cells cannot drive the optokinetic reflex in zebrafish.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Emran F, Rihel J, Adolph AR, Wong KY, Kraves S, Dowling JE
  • Publication date:
    27/11/2007
  • Pagination:
    19126, 19131
  • Journal:
    Proc Natl Acad Sci U S A
  • Volume:
    104
  • Issue:
    48
  • Country:
    United States
  • PII:
    0709337104
  • Language:
    eng
  • Keywords:
    Action Potentials, Aminobutyrates, Animals, Aspartic Acid, Electroretinography, Motion Perception, Nystagmus, Optokinetic, Phosphoric Monoester Hydrolases, Photic Stimulation, Photoreceptor Cells, Retinal Bipolar Cells, Retinal Ganglion Cells, Vision Disorders, Visual Pathways, Zebrafish, Zebrafish Proteins
  • Notes:
    PMCID: PMC2141919
Abstract
Whereas the zebrafish retina has long been an important model system for developmental and genetic studies, little is known about the responses of the inner retinal neurons. Here we report single-unit ganglion cell recordings from 5- to 6-day-old zebrafish larvae. In wild-type larvae we identify at least five subtypes of ganglion cell responses to full-field illumination, with ON-OFF and ON-type cells predominating. In the nrc mutant retina, in which the photoreceptor terminals develop abnormally, we observe normal OFF responses but abnormal ON-OFF responses and no ON responses. Previously characterized as blind, these mutants lack an optokinetic reflex (OKR), but in another behavioral assay nrc mutant fish have near-normal responses to the offset of light and slow and sluggish responses to the onset of light. Pharmacological block of the ON pathway mimics most of the nrc visual defects. We conclude that the abnormal photoreceptor terminals in nrc mutants predominantly perturb the ON pathway and that the ON pathway is necessary to drive the OKR in larval zebrafish.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
Cell & Developmental Biology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by