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Publication Detail
Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium
  • Publication Type:
    Journal article
  • Authors:
    Tietjen I, Rihel J, Dulac CG
  • Publication date:
    2005
  • Pagination:
    201, 207
  • Journal:
    International Journal of Developmental Biology
  • Volume:
    49
  • Issue:
    2-3 SPEC. ISS.
  • Print ISSN:
    0214-6282
Abstract
In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (Lzl) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems. © UBC Press.
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