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Publication Detail
Optimisation of the bolus and infusion protocol for equilibrium magnetic resonance imaging
  • Publication Type:
    Conference
  • Authors:
    Mallik C, Bandula S, Rice S, Atkinson D, Taylor S, Moon J, Punwani S
  • Publication date:
    20/04/2012
  • Pagination:
    4085, ?
  • Status:
    Published
  • Name of conference:
    ISMRM 2012
  • Conference place:
    Melbourne, Australia
  • Conference start date:
    07/05/2012
  • Conference finish date:
    12/05/2012
Abstract
Changes in the fractional volume of the extravascular, extracellular space (VEES) can be indicative of pathology. Equilibrium MRI (EQ-MRI) is a recently proposed technique to measure VEES, provided a constant concentration is reached between the contrast agent in the blood pool and tissue of interest. A pharmacokinetic model of a bolus and infusion protocol was devised to predict an optimal infusion rate and the time when equilibrium would be reached over a range of Ktrans values incorporating both diseased and healthy tissue. Pilot data collected in a control is indicative that equilibrium was reached in normal liver and muscle tissue.
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