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Publication Detail
Tissue engineering: revolution and challenge in auricular cartilage reconstruction.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Nayyer L, Patel KH, Esmaeili A, Rippel RA, Birchall M, O╩╝toole G, Butler PE, Seifalian AM
  • Publication date:
    05/2012
  • Pagination:
    1123, 1137
  • Journal:
    Plast Reconstr Surg
  • Volume:
    129
  • Issue:
    5
  • Country:
    United States
  • PII:
    00006534-201205000-00018
  • Language:
    eng
  • Keywords:
    Biocompatible Materials, Cartilage, Chondrocytes, Ear Cartilage, Ear, External, Humans, Ribs, Stem Cells, Tissue Engineering, Tissue Scaffolds
Abstract
External ear reconstruction for congenital deformity such as microtia or following trauma remains one of the greatest challenges for reconstructive plastic surgeons. The problems faced in reconstructing the intricate ear framework are highly complex. A durable, inert material that is resistant to scar contracture is required. To date, no material, autologous or prosthetic, is available that perfectly mimics the shapely elastic cartilage found in the ear. Current procedure involves autologous costal cartilage that is sculpted to create a framework for the overlying soft tissues. However, this is associated with donor-site morbidity, and few surgeons worldwide are skilled in the techniques required to obtain excellent results. Various alloplastic materials have therefore been used as a framework. However, a degree of immunogenicity and infection and extrusion are inevitable, and results are often disappointing. Tissue-engineered cartilage is an alternative approach but, despite significant progress in this area, many problems remain. These need to be addressed before routine clinical application will become possible. The current tissue-engineered options are fragile and inflexible. The next generation of auricular cartilage engineering is promising, with smart materials to enhance cell growth and integration, and the application of stem cells in a clinical setting. More recently, the authors' team designed the world's first entirely synthetic trachea composed of a novel nanocomposite material seeded with the patient's own stem cells. This was successfully transplanted in a patient at the Karolinska Hospital in Sweden and may translate into a tissue-engineered auricle in the future.
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