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Publication Detail
Hyaluronan hydration generates three-dimensional meso-scale structure in engineered collagen tissues.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Anandagoda N, Ezra DG, Cheema U, Bailly M, Brown RA
  • Publication date:
    07/10/2012
  • Pagination:
    2680, 2687
  • Journal:
    J R Soc Interface
  • Volume:
    9
  • Issue:
    75
  • Country:
    England
  • PII:
    rsif.2012.0164
  • Language:
    eng
  • Keywords:
    Animals, Biocompatible Materials, Cell Survival, Collagen, Fibroblasts, Gels, Humans, Hyaluronic Acid, Microscopy, Electron, Scanning, Rats, Tissue Engineering
  • Notes:
    PMCID: PMC3427506
Abstract
Here, we show that the local incorporation of osmotically active hyaluronan into previously compressed collagen constructs results in further rapid dehydration/compression of collagen layers, channel formation and generation of new interfaces; these novel structures, at the nano-micro (i.e. meso-scale) were formed within native collagen gels, in a highly predictable spatial manner and offer important new methods of fabricating scaffolds (e.g. tubes and open-spirals) with potential for use in tissue regeneration such as in peripheral nerves and small vessels. This paper tests the possibility that the local fluid content of a dense collagen network can be controlled by incorporation of an osmotically active (native) macromolecule--hyluronan. This is an exemplar physiological, osmotic swelling agent. Hyaluronan is commonly secreted by cells deep in connective tissues, so is a good candidate for this role in a cell-driven system balancing mechanical compaction of bulk tissue collagen. These constructs may have potential as functional in vitro models representing developmental and pathological processes.
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