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Publication Detail
Basement membrane protein orchestrates network formation by endothelial cells in 3D: Laminin the conductor
  • Publication Type:
    Conference
  • Authors:
    Stamati K, Priestley JV, Mudera V, Cheema U
  • Publication date:
    07/2011
  • Pagination:
    7
  • Published proceedings:
    European Cells and Materials
  • Volume:
    22
  • Issue:
    SUPPL.3
  • Status:
    Published
  • Name of conference:
    Tissue and Cell Engineering Society (TCES) meeting
  • Conference place:
    University of Leeds
  • Conference start date:
    19/07/2011
  • Conference finish date:
    21/07/2011
  • Print ISSN:
    1473-2262
  • Language:
    English
Abstract
Engineering vascular networks within 3D tissue models is paramount for the survival of cells in large 3D constructs. This is critical for both in vitro and in vivo survival. Our work has focused on network formation by endothelial cells in co-cultures with Human bone marrow stromal cells (HBMSCs) in 3D. We have examined the effect of matrix composition on endothelial cell morphology and our results emphasize the importance of basement membrane proteins for inducing network formation by endothelial cells.
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