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Publication Detail
Mitochondria, calcium-dependent neuronal death and neurodegenerative disease.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Duchen MR
  • Publication date:
    07/2012
  • Pagination:
    111, 121
  • Journal:
    Pflugers Arch
  • Volume:
    464
  • Issue:
    1
  • Status:
    Published
  • Country:
    Germany
  • Language:
    eng
  • Keywords:
    Animals, Calcium, Calcium Channels, Calcium Signaling, Cell Death, Glutamic Acid, Humans, Mitochondria, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Neurodegenerative Diseases, Neurons, Poly(ADP-ribose) Polymerases, Receptors, Glutamate
Abstract
Understanding the mechanisms of neuronal dysfunction and death represents a major frontier in contemporary medicine, involving the acute cell death in stroke, and the attrition of the major neurodegenerative diseases, including Parkinson's, Alzheimer's, Huntington's and Motoneuron diseases. A growing body of evidence implicates mitochondrial dysfunction as a key step in the pathogenesis of all these diseases, with the promise that mitochondrial processes represent valuable potential therapeutic targets. Each disease is characterised by the loss of a specific vulnerable population of cells--dopaminergic neurons in Parkinson's disease, spinal motoneurons in Motoneuron disease, for example. We discuss the possible roles of cell type-specific calcium signalling mechanisms in defining the pathological phenotype of each of these major diseases and review central mechanisms of calcium-dependent mitochondrial-mediated cell death.
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