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Publication Detail
Development and Stability Testing of an MRI Compatible Isolated Tissue System.
  • Publication Type:
  • Authors:
    Richardson S, Siow B, Batchelor A, Lythgoe M, Alexander D
  • Name of conference:
    ISMRM 20th Annual Meeting & Exhibition
  • Conference place:
    Australi, Melbourne
  • Conference start date:
  • Conference finish date:
  • Keywords:
    Diffusion MRI, Electron Microscopy, Electrophysiology, Validation
  • Addresses:
    Simon Richardson
    72 Huntley Street
    WC1E 6DD
  • Notes:
    Poster # 2680
We have developed and validated an MRI compatible chamber to maintain isolated tissue in a structurally and functionally viable and stable condition for acquisition of detailed MRI data sets. We demonstrate that rat optic nerve tissue is structurally and functionally stable within our chamber for 10 h, reflecting the in vivo conditions of the nerve. We use electrophysiology, MR diffusion measurements and electron microscopy to measure the nerve's condition and performance over time. The design offers new opportunities to study viable tissue for example to develop and validate models of diffusion in tissue.
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