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Publication Detail
A specific cognitive deficit within semantic cognition across a multi-generational family.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Briscoe J, Chilvers R, Baldeweg T, Skuse D
  • Publication date:
  • Pagination:
    3652, 3661
  • Journal:
    Proc Biol Sci
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Adolescent, Adult, Aged, Anomia, Case-Control Studies, Child, Child, Preschool, Cognition Disorders, England, Female, Humans, Language, Magnetic Resonance Imaging, Male, Mental Recall, Middle Aged, Neuroimaging, Temporal Lobe
We report a study of eight members of a single family (aged 8-72 years), who all show a specific deficit in linking semantic knowledge to language. All affected members of the family had high levels of overall intelligence; however, they had profound difficulties in prose and sentence recall, listening comprehension and naming. The behavioural deficit was remarkably consistent across affected family members. Structural neuroimaging data revealed grey matter abnormalities in the left infero-temporal cortex and fusiform gyri: brain areas that have been associated with integrative semantics. This family demonstrates, to our knowledge, the first example of a heritable, highly specific abnormality affecting the interface between language and cognition in humans and has important implications for our understanding of the genetic basis of cognition.
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