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Publication Detail
Crystallization, Dehydration, and Phase Transformations of Diastereomeric Salts: L-Ephedrine and D-Tartaric Acid
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Wu H, Jones AG
  • Publication date:
  • Pagination:
    1031, 1038
  • Journal:
    Chemical Engineering and Technology
  • Volume:
  • Issue:
  • Print ISSN:
  • Language:
  • Keywords:
    Chiral resolution, Crystallization, Hydrates, Pharmaceutical products, Polymorphism
A screening of crystallization conditions for the diastereomeric salts formed by L/D-tartaric acid and a common chiral resolving agent, L-ephedrine, in water is reported. Eight different salts with 1:1 and 2:1 stoichiometries were synthesized, identified, and characterized, including three previously reported LL-salts. All new LD-salts were investigated by differential scanning calorimetry, thermogravimetric and elemental analysis, infrared spectroscopy, solid-state NMR, and powder XRD. 1:1 LD-tartrate is anhydrous and 2:1 LD-tartrate crystallizes as a monohydrate; its dehydration and phase transformations on heating were monitored in situ by variable-temperature XRD and hot-stage microscopy. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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