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Publication Detail
Anti-beta2-glycoprotein I, anti-prothrombin and anticardiolipin antibodies in a longitudinal study of patients with systemic lupus erythematosus and the antiphospholipid syndrome
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Inanc M, Donohoe S, Ravirajan CT, Radway-Bright EL, Mackie I, Machin S, Isenberg DA
  • Publication date:
  • Pagination:
    1089, 1094
  • Journal:
    British Journal of Rheumatology
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    ANTIBODIES, Antibody, English, Patient, patients, Adult, ANTIBODIES, Antibodies, Anticardiolipin/Xanalysis, Antinuclear/blood, antigen, Antiphospholipid Syndrome/complications/Ximmunology, assessment, Cerebrovascular Disorders/blood/complications, Cohort, Comparative Study, Complement 3/analysis, disease, DNA, Enzyme-Linked Immunosorbent Assay, Female, Glycoproteins/Ximmunology, IgG, IgG/analysis, IgM/analysis, INCREASE, Longitudinal Studies, Lupus Erythematosus, Systemic/complications/Ximmunology, middle age, NOS, pathogenesis, Prothrombin/Ximmunology, serum, support, non-u.s.gov't, Thrombosis/blood/complications
  • Notes:
    99041095 OBJECTIVE: To determine anti-beta2 glycoprotein-I (anti-beta2GPI) and anti-prothrombin (anti-ProT) antibody levels, and the IgG subclass distribution of anti-beta2GPI antibodies, in serial samples from patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) having initial or recurrent thrombotic/neurological (T/N) events during the study period. To investigate the correlations between these antibodies and beta2GPI antigen, anticardiolipin antibody (aCL), anti-double-stranded (ds) DNA, C3 levels and disease activity. METHODS: Fifty serum samples were identified from seven patients with SLE who had had T/N events during the follow-up from a cohort under long-term follow-up. IgG anti-beta2GPI, anti-ProT, aCL, IgG subclasses of anti-beta2GPI and beta2GPI antigen levels were determined by ELISA. Corresponding disease activity [British Isles Lupus Assessment Group (BILAG)], anti-dsDNA and C3 levels were compared. RESULTS: IgG anti- beta2GPI antibody levels were elevated in six of the patients before and after the T/N events with less marked fluctuations than aCL antibody levels. The predominant subclass of anti-beta2GPI antibodies was IgG2 before and after the T/N events. IgG anti-ProT antibodies were negative in all cases. There was a significant but weak correlation between anti-beta2GPI and aCL antibodies. No correlation was found between disease activity and IgG anti-beta2GPI antibody and beta2GPI antigen levels. There were fluctuations in beta2GPI antigen levels and a trend to increase after T/N events was observed in some patients. CONCLUSION: Most of the patients with a T/N event during the study period had IgG anti-beta2GPI, but not IgG anti-ProT antibodies. Many IgG aCL-negative samples were found to have IgG anti-beta2GPI activity during the follow-up period. The predominant subclass of IgG anti- beta2GPI was IgG2, which may have importance in the pathogenesis of APS. beta2GPI antigen levels were found to be increased in some patients with SLE after T/N events. IgG anti-beta2GPI antibodies may be used as an adjunctive marker of future T/N events in patients with SLE and APS with aCL antibodies and lupus anticoagulant
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