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Publication Detail
β2 glycoprotein-I antigen is increased in primary hyperlipidaemia
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    McNally T, Crook M, Mackie IJ, Isenberg DA, Machin SJ
  • Publication date:
  • Pagination:
    424, 426
  • Journal:
    British Journal of Haematology
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
In order to determine whether elevated levels of β2 glycoprotein-I (β2 GPI) are associated with increased plasma lipids, we measured plasma β2 GPI antigen levels in 47 patients with primary hyperlipidaemia (20 severe hypercholesterolaemia, nine severe hypertriglyceridaemia, and 18 mixed hyperlipidaemia) and 34 normal healthy subjects. Mean β2 GPI levels were significantly increased in each patient group (302.3, 272.9 and 299.1 mg/l, respectively) compared to controls (199.6 mg/l) (P < 0.01). Significant correlations were demonstrated between β2 GPI levels and triglyceride and total cholesterol levels in the control group (r = 0.387, r = 0.559; P < 0.05), but were not observed in all patient groups. These results indicate that β2 GPI is increased in hyperlipidaemia and that its distribution between plasma lipid fractions is perturbed. Plasma lipid levels should therefore be considered when interpreting results of β2 GPI antigen assays.
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